Links – videos, articles, papers
About Great Danes
Video
Playlist on YouTube:
https://www.youtube.com/playlist?list=PL51BA24260F6D4E85
Apologies I have lost links to some of these videos, I will restore when I find them
Taj - August 2005 Video (1) shows Taj having a slow walk with Michael (Isabella making cameo roles) around Roger & Michaels' back yard - then he had a 5 minute tug-of-war
Then video (2) shows him straight after that with Roger. He is in no pain, just runs out of oomph and you can see he does not know he is disabled as he keeps wanting to go on.
Taj - January 2005 These 3 videos show (1) Taj's rear-end instability when walking (2) his bunny hopping when he needs to go faster than a walk (3) the first one in slow motion.
Taj - early September 2004 ·
This video shows Taj playing with his half sister, Isabella. You can see his hips are down and his legs are wobbly - also when he runs, he bunny hops. Since then, Taj has grown at least 4 inches and his rear end wobble is more pronounced. In this video Taj isn't tired - when he tires he slows down, his back end drops towards the ground and he will eventually just stop and lie down for a while. All the symptoms become worse in the heat and this was a cool day.However, it does show that Taj happily plays with Isabella for as long as he can.
And my beautiful assistant is Roger Easton, Isabella's parent.
Other videos The only video of a Great Dane with CCM we could find on the web is at:
http://medicine.ucsd.edu/vet_neuromuscular/cases/2003/dec03.html
Please be aware that this dog has extreme symptoms and the video is distressing to watch. This video works best if you save it to your computer and run it from there.
Scientific papers and articles
These are some of the more significant papers and articles.
2014 There is now a test for IMGD in Great Danes, based on the research of the scientists below:
https://www.pawprintgenetics.com/products/details/78/
June 2013 A paper describing the identification of the genetic cause of the inherited myopathy of Great Danes. This paper describes how the mutation in the muscle-specific exon of BIN1 affects its biological function. It should be of interest for Australian breeders and vets. All affected dogs have exactly the same mutation, which eases molecular diagnosis. So in essence there could now be a test for the genetic mutation that causes this disease. Free access to paper.
"Altered Splicing of the BIN1 Muscle-Specific Exon in Humans and Dogs with Highly Progressive Centronuclear Myopathy". Johann Böhm,Nasim Vasli,Marie Maurer,Belinda Cowling,G. Diane Shelton,Wolfram Kress,Anne Toussaint,Ivana Prokic,Ulrike Schara,Thomas James Anderson,Joachim Weis,Laurent Tiret,Jocelyn Laporte. June 6, 201 DOI: 10.1371/journal.pgen.1003430
March 2008 Our specialist vets, David Davies and Warwick Bruce, published a Case Report in the Australian Veterinary Journal about Taj as the first Australian case of Inherited Myopathy in Great Danes (IMGD)
"Inherited myopathy in a Great Dane". SE Davies, DR Davies, RB Richards and WJ Bruce. Australian Veterinary Journal 2008;86:43–45.
Free to download from link below:
doi: 10.1111/j.1751-0813.2007.00202.x
September 2006 A paper regarding a Candian dog with IMGD which can be downloaded:
Inherited myopathy in a young Great Dane . Chantal J. McMillan, Susan M. Taylor, G. Diane Shelton. Can Vet J 2006;47:899–901 ( PDF, 2.7 MB )
Abstract
A 3-year-old, male Great Dane was evaluated for an 18-month history of progressive weakness. Histologic evaluation of muscle biopsies revealed distinct cytoarchitectural changes that were indistinguishable from the central “core-like” structures previously described as central core myopathy in this breed. Clinical features of this inherited myopathy are described.
May 2006 This review of the disease, which includes Taj as one of the subjects. This article changed the name of the disease to Inherited Myopathy of Great Danes .
"Inherited myopathy of Great Danes". Lujan Feliu-Pascual A, Shelton GD, Targett MP, Long SN, Comerford EJ, McMillan C, Davies D, Rusbridge C, Mellor D, Chang KC, Anderson TJ. Small Animal Practice . 2006 May;47(5):249-54.
The article can be viewed here:
http://onlinelibrary.wiley.com/doi/10.1111/j.1748-5827.2006.00073.x/full
Precis of the paper:
July 2006. A review of similar disease in a young horse
Myopathy with central cores in a foal. Paciello O, Pasolini MP, Navas L, Russo V, Papparella S. Vet Pathol. 2006 Jul;43(4):579-83.
The abstract only can be viewed here:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=16847006
- About Great Danes - http://www.about-great-danes.com/
- The Dane Report, The e-zine for people owned by a Great Dane - http://www.about-great-danes.com/the-dane-report.html
- Great Dane Owners Forum (UK) - http://www.sullyworld.co.uk/newforum/index.php?showtopic=287
- The BARF Diet and book 'Feed Your Dog a Bone' by Dr Ian Billinghurst - http://www.drianbillinghurst.com/
- Amy Marshall's website https://primalpooch.com/why-feed-raw has lots of information. Her book "Why You NEED to Feed Your Dog a Raw Food Diet: A Complete Introduction for Beginners" is really well written and only costs about $5 for Kindle version. You can read it without a Kindle by downloading the Kindle app on your phone.
Video
Playlist on YouTube:
https://www.youtube.com/playlist?list=PL51BA24260F6D4E85
Apologies I have lost links to some of these videos, I will restore when I find them
Taj - August 2005 Video (1) shows Taj having a slow walk with Michael (Isabella making cameo roles) around Roger & Michaels' back yard - then he had a 5 minute tug-of-war
Then video (2) shows him straight after that with Roger. He is in no pain, just runs out of oomph and you can see he does not know he is disabled as he keeps wanting to go on.
Taj - January 2005 These 3 videos show (1) Taj's rear-end instability when walking (2) his bunny hopping when he needs to go faster than a walk (3) the first one in slow motion.
Taj - early September 2004 ·
This video shows Taj playing with his half sister, Isabella. You can see his hips are down and his legs are wobbly - also when he runs, he bunny hops. Since then, Taj has grown at least 4 inches and his rear end wobble is more pronounced. In this video Taj isn't tired - when he tires he slows down, his back end drops towards the ground and he will eventually just stop and lie down for a while. All the symptoms become worse in the heat and this was a cool day.However, it does show that Taj happily plays with Isabella for as long as he can.
And my beautiful assistant is Roger Easton, Isabella's parent.
Other videos The only video of a Great Dane with CCM we could find on the web is at:
http://medicine.ucsd.edu/vet_neuromuscular/cases/2003/dec03.html
Please be aware that this dog has extreme symptoms and the video is distressing to watch. This video works best if you save it to your computer and run it from there.
Scientific papers and articles
These are some of the more significant papers and articles.
2014 There is now a test for IMGD in Great Danes, based on the research of the scientists below:
https://www.pawprintgenetics.com/products/details/78/
June 2013 A paper describing the identification of the genetic cause of the inherited myopathy of Great Danes. This paper describes how the mutation in the muscle-specific exon of BIN1 affects its biological function. It should be of interest for Australian breeders and vets. All affected dogs have exactly the same mutation, which eases molecular diagnosis. So in essence there could now be a test for the genetic mutation that causes this disease. Free access to paper.
"Altered Splicing of the BIN1 Muscle-Specific Exon in Humans and Dogs with Highly Progressive Centronuclear Myopathy". Johann Böhm,Nasim Vasli,Marie Maurer,Belinda Cowling,G. Diane Shelton,Wolfram Kress,Anne Toussaint,Ivana Prokic,Ulrike Schara,Thomas James Anderson,Joachim Weis,Laurent Tiret,Jocelyn Laporte. June 6, 201 DOI: 10.1371/journal.pgen.1003430
March 2008 Our specialist vets, David Davies and Warwick Bruce, published a Case Report in the Australian Veterinary Journal about Taj as the first Australian case of Inherited Myopathy in Great Danes (IMGD)
"Inherited myopathy in a Great Dane". SE Davies, DR Davies, RB Richards and WJ Bruce. Australian Veterinary Journal 2008;86:43–45.
Free to download from link below:
doi: 10.1111/j.1751-0813.2007.00202.x
September 2006 A paper regarding a Candian dog with IMGD which can be downloaded:
Inherited myopathy in a young Great Dane . Chantal J. McMillan, Susan M. Taylor, G. Diane Shelton. Can Vet J 2006;47:899–901 ( PDF, 2.7 MB )
Abstract
A 3-year-old, male Great Dane was evaluated for an 18-month history of progressive weakness. Histologic evaluation of muscle biopsies revealed distinct cytoarchitectural changes that were indistinguishable from the central “core-like” structures previously described as central core myopathy in this breed. Clinical features of this inherited myopathy are described.
May 2006 This review of the disease, which includes Taj as one of the subjects. This article changed the name of the disease to Inherited Myopathy of Great Danes .
"Inherited myopathy of Great Danes". Lujan Feliu-Pascual A, Shelton GD, Targett MP, Long SN, Comerford EJ, McMillan C, Davies D, Rusbridge C, Mellor D, Chang KC, Anderson TJ. Small Animal Practice . 2006 May;47(5):249-54.
The article can be viewed here:
http://onlinelibrary.wiley.com/doi/10.1111/j.1748-5827.2006.00073.x/full
Precis of the paper:
- different disorder to (human) Central Core Myopathy - suggested new name "inherited myopathy in great Danes" (IMGD)
- clinical data from 25 histologically confirmed affected dogs reviewed
- confirmation of diagnosis of IMGD requires testing of muscle biopsy samples
- exercise intolerance, muscle wasting, and exercise-induced tremor; age of onset < 12 months.
- affected puppies are born to clinically unaffected parents
- most affected dogs have a severe form of the disease, occasional dogs may have a less pronounced form and survive into adulthood with an acceptable quality of life
- this myopathy was originally reported in 1987 (Newsholme and Gaskell 1987) and again in 1994 (Targett and others 1994) as a central core myopathy.
- until recently, this myopathy has been confirmed only in the British great Dane population, however confirmed affected great Danes have recently been identified in Canada and Australia
- no cure.
July 2006. A review of similar disease in a young horse
Myopathy with central cores in a foal. Paciello O, Pasolini MP, Navas L, Russo V, Papparella S. Vet Pathol. 2006 Jul;43(4):579-83.
The abstract only can be viewed here:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=16847006